KMID : 0043320070300080927
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Archives of Pharmacal Research 2007 Volume.30 No. 8 p.927 ~ p.931
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A New Pyrrole Alkaloid Isolated from Arum palaestinum Boiss. and its Biological Activities
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El-Desouky S. K.
Kim Ki-Hun Ryu Shi-Young Eweas Ahmad Farouk Gamal-Eldeen Amira M. Kim Young-Kyoon
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Abstract
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The phytochemical analysis of the ethyl acetate fraction of Arum palaestinum Boiss. (Araceae) led to the isolation and identification of a new polyhydroxy alkaloid compound; (S)-3,4,5-trihydroxy-1H-pyrrol-2(5H)-one (1), and other five known compounds; caffeic acid (2), isoorientin (3), luteolin (4) and vicenin II (5), as well as the rare compound 3,6,8-trimethoxy, 5,7,3¡¯,4¡¯-tetrahydroxy flavone (6). The structural elucidations of all the compounds were based on spectroscopic data (1H- and 13C-NMR, DEPT, HSQC, HMBC and NOE difference techniques) and comparison with literature data. Investigation of the antioxidant activity of the ethyl acetate fraction indicated its strong scavenging capacity for 1,1-diphenyl-2-picrylhydrazyl (DPPH) radicals (SC50 3.1¡¾0.82 ¥ìg/mL). Moreover, the treatment of different human cancer cell lines with the ethyl acetate fraction led to dose-dependant suppression in the proliferation of both breast carcinoma cells (MCF-7; IC50 59.09¡¾4.1 ¥ìg/mL) and lymphoblastic leukemia cells (1301; IC50 53.1¡¾2.9 ¥ìg/mL); however, it was found to have no effect on the growth of hepatocellular carcinoma cells (Hep G2).
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KEYWORD
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Arum palaestinum, Araceae, Antioxidant, Cytotoxicity, flavonoids, (S)-3, 4, 5-Trihydroxy-1H-pyrrol-2(5H)-one
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